| Animal model customization |
| serial number | Model type | Model name | Modeling method | Application areas |
| 1 | Digestive System Disease Models | sepsis model | Mixed bacterial infection in the abdominal cavity by cecal ligation and puncture | Simulate sepsis caused by different factors such as infection, trauma, and burns, explore its pathogenesis, find effective treatments, and achieve early diagnosis and intervention. |
| 2 | Irritable bowel syndrome (IBS) model | A variety of chronic unpredictable stress methods (chronic water avoidance, ice water gavage, swimming-induced fatigue, etc.) were used to induce gastrointestinal dysfunction in mice to construct an IBS model. | Suitable for studying the pathogenesis of IBS and drug development |
| 3 | acute colitis model | Mice continuously drank 3%-5% DSS to establish an acute colitis model | The model is similar to the acute phase symptoms of clinical ulcerative colitis in humans, is simple and easy to implement, has a high modeling rate and strong repeatability. Suitable for studying the mechanism of acute colitis and studying the efficacy of drugs |
| 4 | Chronic colitis model | Mice drank 1-3% DSS in certain cycles to establish a chronic colitis model. | This model is similar to the symptoms of human clinical ulcerative colitis in the remission phase, and is suitable for an ideal model of the pathogenesis of ulcerative colitis and drug efficacy. |
| 5 | Functional constipation model | Loperamide inhibits intestinal motility and prolongs content retention time to induce functional constipation in mice | This model has similar characteristics to clinical functional constipation and is often used to screen therapeutic drugs. |
| 6 | Functional diarrhea model | Castor oil induces functional diarrhea in mice
| This model has a short modeling cycle, simulates the pathological characteristics of clinical acute diarrhea, and is often used to evaluate the effect of drug treatment. |
| 7 | Magnesium sulfate induces functional diarrhea in mice | This model is osmotic diarrhea and is suitable for drug screening for the treatment of mild diarrhea. |
| 8 | Non-alcoholic steatohepatitis model | Low-dose, multiple CCl4 injections | This model has a short induction time and a high degree of modeling, which can cause severe liver cirrhosis. Suitable for studying the pathogenesis of clinical liver diseases and the development of drug treatments |
| 9 | A model of non-alcoholic fatty liver disease induced by diet deficient in methionine and choline | This model has a short cycle and is suitable for drug evaluation of drugs that directly exert liver protection. |
| 10 | Establishing fatty liver model using high-fat diet induction or high-fat combined with cholesterol diet | Suitable for studying the histopathology and pathogenesis of early human non-alcoholic steatohepatitis and for early drug screening |
| 11 | Alcoholic steatohepatitis model | Use acute alcohol gavage method to simulate the way the human body ingests alcohol to establish a model | It is suitable for studying the mechanism of acute pathogenesis of alcoholic liver injury. This model has short modeling time and low mortality rate. |
| 12 | Acute Liver Injury Model | Intraperitoneal injection or tail vein injection of CCl₄ in mice results in a short modeling period. | Studying the pathogenesis of clinical liver injury will contribute to the development of clinical therapeutic drugs and treatment research |
| 13 | Gallstone Model | Gallstone formation is induced using a high-cholesterol combined with high-bile-acid diet. | Suitable for the development of gallstone treatment methods and the study of pathogenesis. |
| 14 | Metabolic disease animal models | diabetes model | A high-sugar and high-fat diet combined with intraperitoneal injection of streptozotocin is used to establish an animal model of type 2 diabetes. The operation is simple and the modeling cycle is short. | It can better simulate the pathological symptoms of type 2 diabetes, which is of great significance for studying its pathogenesis, prevention, treatment and drug development. |
| 15 | Hyperuricemia model | Establish a model by intraperitoneally injecting uric acid or potassium oxonate to increase uric acid | Stable and able to reflect clinical pathological characteristics, it is suitable for studying the pathogenesis of hyperuricemia and prevention and treatment drugs. |
| 16 | Hyperlipidemia model | High-fat, high-fructose and high-cholesterol diet induces hyperlipidemia | Suitable for in-depth mechanism research on hyperlipidemia and development of lipid-lowering active substances |
| 17 | obesity model | High-fat diet-induced obesity model in mice |
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| 18 | Diabetic foot model | Intraperitoneal injection of STZ combined with high-fat diet + full-thickness skin resection to induce type 2 diabetic foot model in mice | This model has a high success rate and can better simulate clinical characteristics. It is one of the most widely used animal models currently and is suitable for studying the pathogenesis of diabetic complications and ulcers and the development of therapeutic drugs. |
| 19 | cardiovascular disease models | coronary heart disease model | Myocardial ischemia-reperfusion method to build model | Used to study the pathogenesis of coronary heart disease and the development of myocardial protective drugs and treatment plans |
| 20 | Myocardial infarction model | Model construction by ligating the left anterior descending coronary artery (LAD) | Simulates the pathological process of myocardial infarction, which is suitable for elucidation and exploration of disease mechanisms and achieves better clinical translation. |
| 21 | Atherosclerosis model | High-fat diet induction or ApoE transgenic mouse model construction | It is of great significance to explore the etiology and pathogenesis of AS, explore treatment strategies, and develop preventive and therapeutic drugs. |
| 22 | Hypertension model | Hypertension model induced by intragastric administration of deoxycorticosterone acetate | This model is suitable for studying the pathogenesis of renal hypertension. It can remove a single kidney and shorten the modeling time. |
| 23 | Neurological disease models | Parkinson's model | MPTP induced mouse PD model | One of the best models currently used to study systemic symptoms of PD |
| 24 | depression model | A model of hopeless depression induced by forced swimming | Simple preparation, suitable for studying the pathogenesis of depression and drug screening |
| 25 | Tail suspension experiment induces despair depression model | This model is suitable for antidepressant drug activity screening and has the characteristics of high sensitivity, speed and convenience. |
| 26 | Social defeat stress-induced depression model | This model simulates the pathogenesis of depression at a social level and is particularly suitable for the evaluation of chronic antidepressant treatments. |
| 27 | Chronic restraint stress-induced depression model | This model is simple to prepare, has low irritation, is highly similar to human depression, and is suitable for evaluating overall depression research. |
| 28 | Chronic unpredictable stress-induced depression model | This model is mildly stimulating and highly reliable, and can better simulate human reactions caused by various low-level stimuli in various environments. It is currently considered the most classic model of depression. |
| 29 | tumor model | Orthotopic tumor inoculation model | Orthotopic inoculation of mice with tumor cells to establish an orthotopic model | This model better simulates the physiological state of tumors in the body and has a high degree of clinical similarity. Suitable for studying the deep mechanisms of tumor occurrence and development and evaluating drugs |
| 30 | Subcutaneous tumor-bearing model | Mice were inoculated subcutaneously with tumor cells or human tumor masses
Construction of subcutaneous tumor-bearing model | This model is simple to prepare and easy to observe, and is suitable for large-scale drug screening and evaluation. |
| 31 | Metastasis model | Model construction by injecting tumor cells into tail vein and intraperitoneal cavity | Suitable for studying implantation, growth, angiogenesis, etc. in the late stages of tumor metastasis and screening and testing of drugs for tumor metastasis. |
| 32 | respiratory disease models | acute lung injury model | Endotoxin induces systemic inflammatory response in mice through intraperitoneal/intravenous injection, nasal inhalation, intratracheal instillation, etc. for model creation. | This model is easy to obtain and has good reproducibility, and is currently the most commonly used ALI model in clinical research. |
| 33 | Bronchitis model | Ammonia aerosol-induced bronchitis model in mice | Mice are highly sensitive to ammonia and are easy to prepare. They are suitable for studying the pathogenesis of bronchitis and evaluating the efficacy of therapeutic drugs. |
| 34 | Asthma model | Ovalbumin-induced asthma model in mice | This model can replicate the classic symptoms of asthma such as airway hyperresponsiveness, chronic airway inflammation, and increased mucus. It is a classic animal model for bronchial asthma research. |
| 35 | Immune system related disease models | Rheumatoid Arthritis Model | Collagen-induced RA model in mice | This model has a high success rate and is recognized as a classic RA*** model. It is suitable for treatment effect evaluation and drug screening. |
| 36 | psoriasis model | Imiquimod-induced psoriasis model in mice | This model highly simulates the early and late histopathological phenomena in the course of human psoriasis and is currently the most commonly used model for drug efficacy research. |
| 37 | Osteoporosis model | Ovx surgery induces postmenopausal osteoporosis model in mice | Highly replicates the disease characteristics of postmenopausal osteoporosis. This model is the most recognized model for studying postmenopausal osteoporosis. |
| 38 | Dermatological disease model | Skin defect model | It is prepared by using a special punch, scissors, and blades to remove a certain area of full-thickness skin or segmented tissue on the animal's body surface, usually on the back. | This model is suitable for studying the repair process after skin injury, including inflammatory response, vascular regeneration, and epidermal cell regeneration. |
| 39 | Atopic dermatitis model | Mouse specific dermatitis model induced by exposure to DNCB | This model takes a short time to build and can better simulate Th2-type skin inflammation similar to human atopic dermatitis. It is suitable for studying the underlying mechanism of the disease and evaluating the therapeutic effect. |
| 40 | OVA-induced specific dermatitis model in mice |
| 41 | scratch model | Use a sharp knife to cut the animal skin, creating linear incisions | This model has the characteristics of small damage to accessory organs, fast modeling speed, clear cause of trauma, and fast healing process. It is widely used in trauma research. |
| 42 | Skin scar model | Model constructed using skin scars caused by full-thickness skin defect on the back | The model is simple to prepare and suitable for rapid evaluation of drugs and exploration of deep mechanisms. |
| 43 | Skin aging model | The model was constructed by using excessive intake of D-galactose to induce metabolic disorders, cause cell damage, and lead to decreased body function. | This model is easy to operate, has a high success rate, and is suitable for evaluating the efficacy of drugs. |