Achievements-Shenzhen Gnotobio Biotechnology Co., Ltd.

For Zhujiang Hospital, we constructed a cirrhotic germ-free mouse model, and the related findings revealed a novel mechanism of gut microbiota in hepatic encephalopathy (published in Nature Medicine).2026-03-13

In this study, a germ-free cirrhotic mouse model was repeatedly used to validate the pathogenic role of Ruminococcus gnavus and the neurotoxicity of its metabolite phenylethylamine (PEA). (Conducted by Gnotobio Biotechnology)

For Sun Yat-sen University, we constructed a germ-free mouse tumor-bearing model, and the related findings revealed the mechanism by which gut commensal bacteria enhance the efficacy of immune checkpoint inhibitors (ICB) in solid tumors (published in Canc2026-03-13

In this study, a germ-free mouse tumor-bearing model was used to demonstrate the causal role of A. finegoldii and its enhancing effect on immunotherapy. (Conducted by Gnotobio Biotechnology)

For Sun Yat-sen University, we constructed a germ-free mouse model combining mono-colonization, stress, and colon cancer, and the related findings revealed a novel pathway by which stress mediates gut microbiota to accelerate colon cancer (published in GU2026-03-13

In this study, germ-free mice were used for key causal validation experiments, particularly to demonstrate the pro-metastatic effects of stress-induced microbiota changes (especially the reduction of B. animalis) and OA accumulation. (Conducted by Gnotobio Biotechnology)

For Fudan University, we constructed a germ-free mouse model with mono-colonization, and the related findings revealed that the microbial metabolite PAGln is a driver of aging (published in Nature Aging).2026-03-13

In this study, germ-free mice were used for key mechanistic validation experiments, particularly to demonstrate the causal relationship between gut microbiota changes and PAGln production / cellular senescence. (Conducted by Gnotobio Biotechnology)

For The Chinese University of Hong Kong, we constructed a germ-free mouse model of liver injury with mono-colonization, and the related findings revealed that Klebsiella pneumoniae is a driver bacterium of liver cancer metastasis (published in Nature Micr2026-03-13

In this study, germ-free mice were used to conduct key causal validation experiments on the translocation and pro-tumorigenic mechanisms of HCC-associated microbiota / K. pneumoniae. (Conducted by Gnotobio Biotechnology)

For Sun Yat-sen University, we constructed a germ-free mouse model of colon cancer, and the related findings revealed a key mechanism of interaction between human genetic variation and intratumoral microbiota in colorectal cancer (CRC) progression (publis2026-03-13

In this study, a germ-free mouse tumor-bearing model was used to perform key causal validation of the pro-tumorigenic role of F. nucleatum in the context of low KCNJ11 expression. (Conducted by Gnotobio Biotechnology)

For Sun Yat-sen University, we constructed a pseudo-germ-free mouse model of orthotopic liver cancer, and the related findings revealed the key role of the gut microbiota in oncolytic virus therapy for liver cancer (published in Nature Communications).2026-03-13

In this study, antibiotic-treated (ABX) pseudo-germ-free mice were used for key causal validation experiments, particularly to demonstrate that the presence of gut microbiota limits oncolytic virus efficacy, as well as the protective effect of L. acidophilus supplementation. (Conducted by Gnotobio Biotechnology)

For Southern Medical University, we constructed a germ-free mouse model with dietary restriction and FMT transplantation, and the related findings elucidated a novel mechanism by which dietary restriction regulates the gut microbiota to alleviate sepsis-i2026-03-13

In this study, germ-free mice were used to conduct key causal validation experiments to demonstrate the causal role of gut microbiota changes (particularly the microbiota remodeling induced by time-restricted feeding, TRF) and 3-HB production in the protection against sepsis-induced liver injury. (Conducted by Gnotobio Biotechnology)

For Fudan University, we constructed an antibiotic-treated (ABX) pseudo-germ-free colonization mouse model, and the related findings revealed how gut lactic acid and its key microbial mediators alleviate anxiety (published in Gut Microbes).2026-03-13

In this study, antibiotic-treated (ABX) pseudo-germ-free mice were used to conduct key causal validation experiments to demonstrate the role of gut microbiota in tryptophan metabolism and anxiety regulation. (Conducted by Gnotobio Biotechnology)