SPF Animals

SPF (Specific Pathogen-Free) animals are standard laboratory animals bred in barrier environments that are free from research-interfering pathogens but maintain a normal microbiota. They serve as the "gold standard" material for modern biomedical research. Through strict microbiological control and regular testing, they eliminate the interference of latent infections on experimental results, thereby ensuring the accuracy and reproducibility of scientific data as well as the biosafety of experimental procedures.

Strain Background

An inbred strain with an albino coat color. It has a relatively docile temperament. Renowned for its favorable immune response characteristics, particularly its propensity to develop plasmacytomas, it is the classic strain for monoclonal antibody production.

Application Areas

● Immunology and Antibody Engineering: The gold standard strain for monoclonal antibody production (e.g., hybridoma technology) and the study of germinal center reactions.

● Infectious Disease Research: Susceptible to many pathogens (e.g., Leishmania, Streptococcus pneumoniae), serving as an important model for studying infection and immunity.

● Oncology: Commonly used for ascites tumor models (e.g., S180) and breast cancer models (e.g., 4T1).

● Vaccinology: Used to evaluate the immunogenicity and efficacy of vaccines.

Applicable Scenarios

● Development and production of monoclonal antibodies.
      ● Study of intracellular parasite infections such as leishmaniasis.
      ● Establishment of ascites tumor models requiring intraperitoneal inoculation.
      ● Evaluation of whether vaccines or adjuvants can effectively induce a strong antibody response.