SPF Animals

SPF (Specific Pathogen-Free) animals are standard laboratory animals bred in barrier environments that are free from research-interfering pathogens but maintain a normal microbiota. They serve as the "gold standard" material for modern biomedical research. Through strict microbiological control and regular testing, they eliminate the interference of latent infections on experimental results, thereby ensuring the accuracy and reproducibility of scientific data as well as the biosafety of experimental procedures.

Strain Background

An inbred strain with black coat color. It is the first mouse strain to have its genome fully sequenced and is regarded as the "standard" laboratory mouse. It is relatively active and aggressive in temperament, and is sensitive to diet-induced obesity, atherosclerosis, and type II diabetes.

Application Areas

● Genetics and Genomics: Serves as a background strain for generating genetically engineered mice (e.g., knockout, knock-in).

● Metabolic Diseases: The preferred model for studying obesity, diabetes, and atherosclerosis.

● Neuroscience: Widely used in behavioral and neurodegenerative disease research.

● Immunology: Commonly used in autoimmune disease and infection immunity research (though it exhibits a strong Th1-type immune response).

● Oncology: Used to establish various syngeneic tumor transplantation models.

Applicable Scenarios

● When generating or breeding genetically modified mice, C57BL/6J is often chosen as the genetic background.
      ● Studying high-fat diet-induced metabolic syndrome.
      ● Conducting complex behavioral tests (e.g., learning and memory, anxiety and depression).
      ● Studying Th1-cell-mediated autoimmune diseases such as multiple sclerosis (EAE model).